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Network with your peers at Brain Disorders 2019

Explore highlights here: https://braindisorders.neuroconferences.com/ Brain Disorders 2019 meeting will be accompanied with many professional attributes of great quality, and the selected venue will allow conference speakers and attendees opportunities to engage in collaborative efforts while learning more about some of the current trends and research practices applied to address factors relative to brain disorders and its therapy. Its the oppurtunity for interested participants in this field of #Neuroscience to globalize their research work.

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Parkinson's disease and Neurosurgery

The first-line treatment forParkinson disease(PD), levodopa paired with carbidopa, did more than revolutionize treatment for PD when it entered use in the 1960s, it also largely replaced the use of neurosurgeries, especially pallidotomy and thalamotomy, that had been used in PD care since the beginning of the 20th century.

When it became evident that patients would experience dyskinesias and on/off periods after long-term use of levodopa, whether from the drug itself or from the disease's progression, attention returned to pallidotomy and thalamotomy in the 1990s.

Several experimental therapies for PD have so far dead-ended. Gamma-knife thalamotomy enjoyed brief interest but has now fallen by the wayside for PD nearly everywhere because of its high-risk adverse effect profile, Dr Martello said. Stem cell transplantation has similarly shown too many adverse effects, and gene therapy simply has not shown much benefit.

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New therapeutic target of intractable epilepsy identified in pediatric tumors

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Pediatric brain tumors are characterized by frequent complications due to intractable epilepsy compared to adult brain tumors. However, the genetic cause of refractory epilepsy in pediatric brain tumors has not been elucidated yet, and it is difficult to treat patients because the tumors do not respond to existing antiepileptic drugs and debilitate children's development. The research has been conducted by ateam led by Professor Jeong Ho Le.

A Korean research team led by Professor Jeong Ho Lee of the Graduate School of Medical Science and Engineering at the Korea Advanced Institute of Science and Technology (KAIST) has recently identified a neuronal BRAF somatic mutation that causes intrinsic epileptogenicity in pediatric brain tumors. Their research results were published online in Nature Medicine. DOI: 10.1038/s41591-018-0172-x

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Salt Can Trigger Inflammation in Multiple Sclerosis

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A new study reports salt could be a possible trigger for inflammation in multiple sclerosis. Researchers report cells in a high salt environment show activation of the beta catenin/Wnt signaling pathway, a pathway previously implicated in disrupting regulatory T cells and triggering inflammation.

"The risk of developing MS is thought to increase by interaction between relatively common genetic variants and environmental factors. In addition to salt, vitamin D deficiency, smoking, and obesity have been linked to development of MS", researchers say.





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