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Parkinson's disease and Neurosurgery

The first-line treatment forParkinson disease(PD), levodopa paired with carbidopa, did more than revolutionize treatment for PD when it entered use in the 1960s, it also largely replaced the use of neurosurgeries, especially pallidotomy and thalamotomy, that had been used in PD care since the beginning of the 20th century.

When it became evident that patients would experience dyskinesias and on/off periods after long-term use of levodopa, whether from the drug itself or from the disease's progression, attention returned to pallidotomy and thalamotomy in the 1990s.

Several experimental therapies for PD have so far dead-ended. Gamma-knife thalamotomy enjoyed brief interest but has now fallen by the wayside for PD nearly everywhere because of its high-risk adverse effect profile, Dr Martello said. Stem cell transplantation has similarly shown too many adverse effects, and gene therapy simply has not shown much benefit.

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New therapeutic target of intractable epilepsy identified in pediatric tumors

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Pediatric brain tumors are characterized by frequent complications due to intractable epilepsy compared to adult brain tumors. However, the genetic cause of refractory epilepsy in pediatric brain tumors has not been elucidated yet, and it is difficult to treat patients because the tumors do not respond to existing antiepileptic drugs and debilitate children's development. The research has been conducted by ateam led by Professor Jeong Ho Le.

A Korean research team led by Professor Jeong Ho Lee of the Graduate School of Medical Science and Engineering at the Korea Advanced Institute of Science and Technology (KAIST) has recently identified a neuronal BRAF somatic mutation that causes intrinsic epileptogenicity in pediatric brain tumors. Their research results were published online in Nature Medicine. DOI: 10.1038/s41591-018-0172-x

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Salt Can Trigger Inflammation in Multiple Sclerosis

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A new study reports salt could be a possible trigger for inflammation in multiple sclerosis. Researchers report cells in a high salt environment show activation of the beta catenin/Wnt signaling pathway, a pathway previously implicated in disrupting regulatory T cells and triggering inflammation.

"The risk of developing MS is thought to increase by interaction between relatively common genetic variants and environmental factors. In addition to salt, vitamin D deficiency, smoking, and obesity have been linked to development of MS", researchers say.





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Differences in Brains of Women and Men with Schizophrenia

Researchers have identified key differences between the way males and females with schizophrenia process the emotional states of others than those without the condition. The study reports those with schizophrenia use less complex brain regions than healthy controls to process other people’s emotions.

The research teamfrom the Icahn School of Medicine at Mount Sinai found that females without schizophrenia used more complex areas of their brains to identify someone else’s mental state, including other’s beliefs, desires, intentions, and emotions. The healthy males used less complex brain regions to process others’ mental states.Both women and men with schizophrenia used less complex brain regions to process the emotional states of others. Men with schizophrenia used less complex brain regions for processing than healthy men.

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Dementia due to Huntington disease

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Huntington's disease (HD), also known as Huntington's chorea, is an inherited disorder that results in death of brain cells. The earliest symptoms are often subtle problems with mood or mental abilities. A general lack of coordination and an unsteady gait often follow. Mental abilities generally decline into dementia.
To share your research to prevent and cure #Huntingtons disease join Brain disorders conferences and be a part of a global movement towards brain disorders and therapeutics.



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Globalize your research at Brain Disorders 2019 conference

Brain Disorders 2019 is programmed in a way which will bring you the most recent information on brain disorders and its therapy with a demanding theme of “Discovering methods to combat against brain complications”. We take immense pleasure to welcome you for the participation in our esteem conference. This conference will provide a forum for exchange of ideas and authoritative views by leading scientists as well as business leaders and investors in this exciting field. Outstanding keynote speakers and well-known leading scientists and experts from across the globe will be expected to share their knowledge.We look forward to greet you at Brussels, Belgium. To join visit and explore: Brain Disorders ConferencesBrain Disorders Conferences Neurology Conferences | Neurology Congress | Neurologists Meeting | Neuroscience Conferences | Brain damage Conferences | Bipolar disorder Conferences | Huntington's disease Conferences | Addiction Conferences | Migraine Conferences | Degenera…

Do you know the effect of alcohol consumption on brain during adolescence

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"Alcohol consumption is a risk factor for accidents, mental illnesses or other pathologies, as well as for the appearance of addictions, including alcoholism. An interesting topic to study is the damage that alcohol induces on the central nervous system (CNS) in the young population. The brain undergoes substantial modifications during adolescence, making brain cells more vulnerable to the ethanol toxicity. Over the last years, the brain mitochondria have emerged as a cell organelle which is particularly susceptible to alcohol. Mitochondria suffer severe alterations which can be exacerbated if the amount of alcohol or the exposure time is increased. In this review, we focus on the changes that the adolescent brain undergoes after drinking, placing particular emphasis on mitochondrial damage and their consequences against brain function."

To know more access this article from BDR free: https://onlinelibrary.wiley.com/doi/10.10…